Just another manic…tuesday

I have had way way way WAY too much caffeine today.Which, luckily, meant I accomplished more today than I have in a week. Hurrah! Accordingly, I’ve (respectfully) made an addition to Jorge Cham’s grad student motivational graph:If that little peak were obnoxiously loud red or manically hot pink, it’d mimic my mental state pretty darn closely. UPDATE:All right, in response to a comment that was just posted on caffeinated soap, I’ll cite this article that assessed the permeability and transdermal absorption of three difference compounds - one of which is caffeine - on human skin grafts (yes, ew).The most relevant results are found on the graph on p828, where the permeability of caffeine (abbreviated ‘CF’ and marked w/ filled triangles) is measured over time. I’m no pharmacologist, but that looks like a pretty puny amount of trans-dermal absorption. And check out the timeframe.Nevermind how much absorption to expect in a running shower with a bar of lightly caffeinated soap that you’re slathering all over your body. The water bath used for the skin grafts was 37 degrees C, which is shower-able, but the time frame used in the study is just a tad bit longer than I think Al Gore would like us to shower for (first timepoint on graph is 2hr). The soap manufacturer’s state that each “serving” contains 200mg of caffeine, which is a solid two cups of coffee, but I’d like to see some measurements of serum caffeine levels after all’s said and done.So there you have it - caffeinated soap, debunked.UPDATE: William Saletan of Slate commented on this, too…but I beat him to it (Source: The Anterior Commissure)

The original source

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